PREDVIĐANJE ALFABETA LOKALNE STRUKTURE PROTEINA PRIMENOM METODA ISTRAŽIVANJA PODATAKA

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PREDVIĐANJE ALFABETA LOKALNE STRUKTURE PROTEINA PRIMENOM METODA ISTRAŽIVANJA PODATAKA

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dc.contributor.advisor Mitić, Nenad
dc.contributor.author Maljković, Mirjana
dc.date.accessioned 2021-08-06T13:15:15Z
dc.date.available 2021-08-06T13:15:15Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/123456789/5236
dc.description.abstract Proteins are linear biological polymers composed of amino acids whose structure and function are determined by the number and order of amino acids. The structure of the protein has three levels: primary, secondary and ter- tiary (three-dimensional, 3D) structure. Since the experimental determination of protein 3D structure is expensive and time-consuming, it is important to develop predictors of protein 3D structure properties from the amino acid sequence (pri- mary structure), such as 3D structure of the protein backbone. The 3D structure of the backbone can be described using prototypes of local protein structure, i.e. prototypes of protein fragments with a length of few amino acids. A set of local structure prototypes determines the library of local protein structures, also called the structural alphabet. A structural alphabet is defined as a set of N proto- types of L amino acid length. The subject of this dissertation is the development of models for the prediction of structural alphabet prototypes for a given amino acid sequence using different data mining approaches. As one of the most known, structural alphabet Protein Blocks (PBs) was used in one part of the doctorial re- search. Structural alphabet PBs consists of 16 prototypes that are defined using fragments of 5 consecutive amino acids. The amino acid sequence is combined with the structural properties of a protein that can be determined based on amino acid sequence (occurrence of repeats in the amino acid sequence) and results of predictors of protein structural properties (backbone angles, secondary structures, occurrence of disordered regions, accessible surface area of amino acids) as an input to the prediction model of structural alphabet prototypes. Besides the de- velopment of models for prediction of prototypes of existing structural alphabet, the analysis of the capability of developing new structural alphabets is researched by applying the TwoStep clustering algorithm and construction of models for the prediction of prototypes of new structural alphabets. Several structural alpha- bets, which differ in the length of prototypes and the number of prototypes, have been constructed and analyzed. Fragments of the large number of proteins, whose structure is experimentally determined, were used to construct the new structural alphabets. en_US
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dc.language.iso sr en_US
dc.publisher Beograd en_US
dc.title PREDVIĐANJE ALFABETA LOKALNE STRUKTURE PROTEINA PRIMENOM METODA ISTRAŽIVANJA PODATAKA en_US
mf.author.birth-date 1986-11-13
mf.author.birth-place kambera en_US
mf.author.birth-country Australija en_US
mf.author.residence-state Srbija en_US
mf.author.citizenship Srpsko en_US
mf.author.nationality Srpkinja en_US
mf.subject.area Computer science en_US
mf.subject.keywords data mining, structural alphabet, prediction model, Protein Blocks en_US
mf.subject.subarea data mining, bioinformatics en_US
mf.contributor.committee Malkov, Saša
mf.contributor.committee Kovačević, Jovana
mf.contributor.committee de Breven, Alexandre
mf.university.faculty Mathematical faculty en_US
mf.document.references 88 en_US
mf.document.pages 149 en_US
mf.document.location Beograd en_US
mf.document.genealogy-project No en_US
mf.university Belgrade University en_US

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