Razvoj multifunkcionalne bioinformatičke platforme zasnovane na potencijalu elektron-jon interakcije bioloških molekula

eBiblioteka

 
 

Razvoj multifunkcionalne bioinformatičke platforme zasnovane na potencijalu elektron-jon interakcije bioloških molekula

Show simple item record

dc.contributor.advisor Tošić, Dušan
dc.contributor.author Perović, Vladimir
dc.date.accessioned 2016-06-21T14:06:27Z
dc.date.available 2016-06-21T14:06:27Z
dc.date.issued 2013
dc.identifier.uri http://hdl.handle.net/123456789/4230
dc.description.abstract Although long-range intermolecular interactions (interactions acting on distances >5Å) play an important role in recognition and targeting between molecules in biological systems, there is no one appropriate software package allowing use of this important property in investigation of biologically active molecules. The multifunctional EIIP/ISM software, which is based on physical parameters determining long-range molecular properties, was developed in this thesis. This novel and unique platform allows (i) investigation of protein-protein and protein-small molecule interactions, (ii) analysis of structure/function relationship of proteins, (iii) assessment of biological effects of mutations in proteins, (iv) monitoring of the functional evolution of proteins, (v) ―de novo‖ design of molecules with desired biological function and (vi) selection of candidate therapeutic molecules. Results of application of the EIIP/ISM platform on diverse problems (e.g. the evolution of influenza A viruses, assessment of biological effects of mutations on the LPL protein, representing a risk factor for cardiovascular diseases, identification of therapeutic targets for HIV and influenza viruses, virtual screening of molecular libraries for candidate antibiotics and anti-HIV drugs) which are presented in this thesis, confirm the applicability of this platform on broad spectrum of problems in molecular biology, biomedicine and pharmacology. en_US
dc.description.provenance Submitted by Slavisha Milisavljevic (slavisha) on 2016-06-21T14:06:27Z No. of bitstreams: 1 phdPerovic_Vladimir.pdf: 11958805 bytes, checksum: adb067b7912e9f59edf0b80fbd9be683 (MD5) en
dc.description.provenance Made available in DSpace on 2016-06-21T14:06:27Z (GMT). No. of bitstreams: 1 phdPerovic_Vladimir.pdf: 11958805 bytes, checksum: adb067b7912e9f59edf0b80fbd9be683 (MD5) Previous issue date: 2013 en
dc.language.iso sr en_US
dc.publisher Beograd en_US
dc.title Razvoj multifunkcionalne bioinformatičke platforme zasnovane na potencijalu elektron-jon interakcije bioloških molekula en_US
mf.author.birth-date 1976-02-09
mf.author.birth-place Beograd en_US
mf.author.birth-country Srbija en_US
mf.author.residence-state Srbija en_US
mf.author.citizenship Srpsko en_US
mf.author.nationality Srbin en_US
mf.contributor.committee Veljković, Veljko
mf.contributor.committee Živković, Miodrag
mf.university.faculty Mathematical Faculty en_US
mf.document.pages 278 en_US
mf.document.location Beograd en_US
mf.document.genealogy-project No en_US
mf.university Belgrade University en_US

Files in this item

Files Size Format View
phdPerovic_Vladimir.pdf 11.95Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record